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Additionally, purines function as metabolic signals and play crucial roles in the central nervous system, particularly in the functioning of neuronal and glial cells (Fumagalli et al., 2017)

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To exclude any artifacts from an irreversible interaction between -arrestin and receptor in the PathHunter assay, we visualized GFP-tagged -arrestin-2 in MIN6B1-SNAP-GLP-1R cells, showing that exendin-4 and exendin-asp3, but not exendin-phe1, induce robust translocation to SNAP-GLP-1R-positive PM and endosomes (Fig