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Nmeth and Boda measured a xanthine oxidase activity index and a GSSG/GSH ratio in infants and children with septic shock and showed that these indices were significantly correlated with each other, with severity of illness scores (PRISM), and were increased in patients in a proinflammatory state (26)

In animal models, researchers measure parameters such as circulating free fatty acids, respiratory exchange ratios, and adipose tissue gene expression to characterize shifts in substrate utilization

They bind the GHS-R1a receptor and stimulate GH release through a separate pathway