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Despite this, neurons generate less and less energy over time, leading to impaired synaptic activity, reduced cell repair, mitogenesis, autophagy, the accumulation of misfolded proteins, and finally, to cell death

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115 Glutathione deficiency is associated with chronic bronchitis, COPD, cystic fibrosis, idiopathic pulmonary fibrosis, bacterial and viral infections, and toxicity of various foreign compounds (smoke, pollutants, and drugs)

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