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demonstrated that Ox-LDL, a potent pro-atherosclerotic factor, induces ferroptosis in mouse aortic endothelial cells by increasing iron deposition, lipid peroxides, and ROS while decreasing GPX4 levels

Transport studies in polarized HepaRG cells show that ZIP14-mediated Mn transport is downregulated in the presence of high extracellular Mn (Thompson and Wessling-Resnick, 2019)

It may offer neuroprotective, angiogenic, wound healing and tissue growth propertiesand all of these benefits have been noted in preclinical studies, although human research is severely lacking