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Cell Rep 17 (3): 821836

Foundational work from the de Keizer laboratory (Baar et al., Cell, 2017) reported that the peptide perturbs the FOXO4-p53 association, leading to p53 nuclear exclusion and apoptosis that appeared preferential to senescent cells in cultured cells and aged mouse models

Besides providing this neuronal energy support, MCTs and lactate play an active role in neural and synaptic plasticity and function, learning, and memory (Dringen et al., 1993

CD36 activation by lipid peroxidation products, like 4-hydroxy-trans-2-nonenal (4HNE), leads to the induction of ER stress markers such as phospho-ATF4 and CHOP in endothelial cells