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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Providing basal insulin to patients with type 1 diabetes who are NPO helps maintain glycemic control and prevents the onset of DKA

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Key management considerations include: Continuing prescribed arthritis medications (disease-modifying agents, corticosteroids) as directed Monitoring for new or worsening joint symptoms that may require evaluation Maintaining adequate protein intake (generally 0.8-1.0 g/kg body weight, individualized based on age and kidney function) to preserve muscle mass during weight loss Ensuring sufficient calcium and vitamin D for bone health Reporting severe joint pain, swelling, or functional limitation promptly Patients should seek medical evaluation if they experience sudden onset of severe joint pain, joint swelling with redness or warmth, inability to bear weight, joint symptoms accompanied by fever, or persistent pain lasting more than 6 weeks