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Most commonly reported: Nausea (most common, particularly during dose escalation) Diarrhea Vomiting Constipation Abdominal discomfort These effects were generally mild to moderate in severity and tended to diminish as participants adjusted to the treatment, particularly when gradual dose escalation protocols were followed
Higher body weight can also reduce the response to some disease-modifying antirheumatic drugs (DMARDs) and biologic medications
The American Diabetes Association's Standards of Care acknowledge the ongoing uncertainty, noting that while pancreatitis has been reported with GLP-1 receptor agonist use, a definitive causal relationship has not been established
Prevention of cardiorenal complications in people with type 2 diabetes and obesity
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