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A rigorous LC-MS pharmacokinetic study in rats would provide a definitive reference

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In the case of nicotine, preclinical studies showed evidence that the rewarding effects of nicotine are reduced by stimulation of GLP-1 receptors in the medial habenula, which is a brain region that mediates nicotines aversive effects [48]

It should not be automatically substituted for L-carnitine L-tartrate in sports formulas without reviewing target market, dose, taste, and product format