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Reduces absorption rate and increases localized irritation

This suggests that retatrutide, despite its potency, will likely require a long-term maintenance strategypotentially involve lower maintenance doses once weight loss targets are achieved

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[27] demonstrated that GIP receptor neurons differ in their connectivity, transcriptomic profile, peripheral accessibility, and appetite-controlling mechanisms with vast heterogeneity of the central GIP receptor signalling axis and further studies are needed to clarify the effects of GIP pharmacology on feeding behavior