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[2] Additionally, findings from SURPASS-1 and SURPASS-2 highlight the importance of gradual dose increases to improve patient adherence and reduce dropouts

Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH

A diet rich in fatty foods can lead to fat accumulation in the intestines, contributing to weight gain

Do not scratch or pick the spots