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The cellular antioxidant system comprises enzymes such as superoxide dismutases (SOD), catalase, glutathione peroxidases and peroxiredoxins, together with low-molecular-weight molecules (glutathione, uric acid, vitamins C and E, bilirubin and coenzyme Q)
However, since these trends are observed in the sibling study cohort who share a household, overall lifestyle, and likely comparable access to dietary selenium this finding warrants a deeper investigation into the actual causes of these protein differences between siblings discordant for konzo
Garca-Domnguez M (2024) Enkephalins and pain modulation: mechanisms of action and therapeutic perspectives