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Another pathognomonic feature of LAL-D is birefringent cholesterol ester crystals in hepatocytes and Kupffer cells, using polarized light on electron microscopy

On April 11, 2019, the American College of Veterinary Internal Medicine's (ACVIM) Specialty of Cardiology consensus panel (consisting of ten board certified veterinary cardiologists) published revised guidelines for the diagnosis and treatment of mitral valve disease (MVD) in dogs