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(2000) Heffernan, Jiang, Thorburn, and Ng evaluated the metabolic effects of orally administered AOD-9604 in rodent models and the lipolytic activity of the compound on isolated human adipose tissue ex vivo
Improved circulation to extremities is a less common but notable report
These outcomes highlight challenges such as inter-individual differences (what works in one persons gut may not in anothers), timing (intervening too late in disease may limit benefits), and the need for biomarkers to identify who is most likely to respond
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