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In addition, treatment with Bifidobacterium animalis A6 has been shown to ameliorate renal fibrosis and glomerulosclerosis by decreasing the relative abundance of toxin-producing species, such as Eggerthella lenta and Fusobacterium , and by reducing serum levels of uremic toxins, creatinine, and urea in CKD rats [110]

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4.1 Enzymatic mechanisms 4.1.1 The glutathione (GSH)-GPX4 axis Ferroptosis is characterized by the hallmark feature of intracellular lipid peroxide accumulation, with the glutathione-glutathione peroxidase 4 (GSH-GPX4) axis playing a pivotal role in suppressing lipid peroxidation

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