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The inflammatory environment in AD triggers the release of cytokines such as interleukin-1 (IL-1) and tumor necrosis factor- (TNF-), which can reduce GLUT expression in brain cells

As expected, endo-IWR1, a specific inhibitor of canonical Wnt/-catenin signaling by increasing degradation of -catenin 25,26 , substantially reduced the expression of -catenin in a dose-dependent manner (Supplementary Figure 4a)