mechanism of semaglutide (Ozempic, Wegovy, Rybelsus) Mechanism of Semaglutide in MASLD

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Semaglutide Phase 3 Results (STEP 1) The Phase 3 STEP 1 trial enrolled 1,961 adults with overweight or obesity (BMI 27 with comorbidities or BMI 30) without diabetes (Wilding 2021, NEJM): 2.4 mg weekly: 14.9% body weight reduction at 68 weeks Placebo arm: 2.4% body weight reduction at 68 weeks Responder rates: 86% of subjects on semaglutide achieved 5% weight reduction

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