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Do not use on cuts wounds or other open areas of skin

There is a lot of excitement and demand for these medications, but side effects are critical points for discussion, Prateek Sharma, MD, a Professor of Medicine in the Department of Medical Oncology at the University of Kansas School of Medicine, and lead investigator of the study, told Healthline

Interestingly, relatively low concentrations of E2 are capable of robustly inhibiting germ cell apoptosis in cultured segments of human seminiferous tubules without survival factors (i.e., serum and hormones)