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Whats clearer is that perimenopausal women on GLP-1 often experience changes in cycle pattern that overlap with normal perimenopausal changes

A recent study evaluating gastric emptying with tirzepatide (Mounjaro) and oral contraceptives found that a single 5mg dose of tirzepatide was associated with an approximate 20% decrease in the amount of the oral contraceptive absorbed into the bloodstream

Additionally, racial differences were observed, with Black patients showing a higher risk of suicidal ideations or attempts (3.45, 95% CI: 2.864.17) compared to White and Asian patients

One study finds individuals with obesity are 18% to 55% more likely to develop depression