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The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M

There are a number of inborn errors of metabolism that are characterised by a failure of this conjugation process, but the classical example is that of the CriglerNajjar * syndrome [5], where there are high serum levels of unconjugated bilirubin due to defects in the UDPGT gene

The NIH factsheet explains that no tolerable upper intake level has been set for B12, because it has a low potential for toxicity in healthy people

We ensure our formulations contain no synthetic fillers, no GMOs, and are produced in GMP-aligned facilities