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Weight loss medications approved by the FDA include GLP-1 receptor agonist drugs, such as Wegovy (semaglutide), Zepbound (tirzepatide), and Saxenda (liraglutide)

The relative changes in the penile erectile function between l-ARG subgroups of patients with mildmoderate and severe vasculogenic ED are shown in Table 4

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Maximum weight loss is the primary goal Previous GLP-1 medications caused intolerable nausea You have concurrent type 2 diabetes needing aggressive treatment You have plateaued on Semaglutide and need additional weight loss Insurance covers Zepbound or cost is not a barrier Patients prioritizing maximum weight loss and who tolerate the medication well typically do better with Tirzepatide