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Dual Incretin Signaling# GLP-1R activation : Enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, reduces appetite via hypothalamic signaling GIPR activation : Potentiates insulin secretion, may improve lipid metabolism and fat distribution, enhances central appetite regulation Synergistic effects : The combination produces greater glycemic and weight effects than either pathway alone Pharmacokinetics# The C20 fatty diacid modification enables albumin binding, yielding a half-life of approximately 5 days and supporting once-weekly administration

In the body, ALA performs three key roles in cellular health

doi: 10.1016/j.redox.2018.01.008 26 ColditzG.BranchL.LipnickR.WillettW.RosnerB.PosnerB.et al

2f,g) and significantly reduced body weight (Extended Data Fig