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Gallbladder disease: Cholelithiasis (gallstones) and cholecystitis have been reported with GLP-1 receptor agonist therapies and may also occur with rapid weight loss
Temporary Amenorrhea (No Periods): In exceptional instances, women may completely cease menstruation for some time until their bodies get used to the metabolic changes brought about by Semaglutide
An additional recent study found that GLP-1 action on human pancreatic islet alpha-cells was mediated independently of any paracrine signalling, as preventing insulin and somatostatin signalling did not affect the inhibition of glucagon secretion
GLP-1 is a gut hormone secreted by L-cells in the distal intestine in response to neural, nutritional, and hormonal stimuli, primarily postprandially
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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