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Rodents receiving GLP-1 receptor agonists developed dose-dependent increases in C-cell hyperplasia

Visual clarity tells you that gross degradation has not occurred

In 2024, it was also approved to Zepbound treat obstructive sleep apnea in adults with obesity

In pregnant female rats given subcutaneous doses of 0.1, 0.25 and 1.0 mg/kg/day liraglutide from gestation day 6 through weaning or termination of nursing on lactation day 24, estimated systemic exposures were 0.8-, 3-, and 11-times human exposure at the MRHD of 1.8 mg/day, based on plasma AUC