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Tsuboi et al

2020;9(Suppl 2):S149-S159

The Dual-Agonist Difference Tirzepatide is a dual-acting medication that activates two different receptor systems: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

Extending fasting to 18+ hours requires individual assessment because the combination intensifies metabolic demands on liver glycogen and electrolyte balance