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For example: Serious cardiovascular disease usually rules out stimulants like phentermine Uncontrolled high blood pressure a problem for some medicines Seizure disorders, bipolar disorder or eating disorders important when considering naltrexone/bupropion History of pancreatitis or severe gut disease needs caution with GLP1 medications Pregnancy or breastfeeding weight loss drugs are generally not used This is why Australian regulators and RACGP stress that obesity pharmacotherapy needs careful selection and monitoring , not casual prescribing

These agents are relatively ineffective as monotherapy in African American patients

That knee laxity in women peaks when estrogen levels decline between ovulation and post-ovulation is indictive of estrogens effect on connective tissue (43)

Although our findings do not rule out the possibility of an increased risk of non-arteritic anterior ischemic optic neuropathy when using semaglutide for obesity, the low number of observed events suggests that any potential risk is likely of limited absolute magnitude, Professor Pottegrd added