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Heat, moisture, oxygen exposure, light, and repeated warming can still reduce quality over time

These transmembrane proteins connect the internal cytoskeleton to the extracellular matrix, enabling cells to sense and respond to their environment

Variants in JAK2, TYK2, STAT1, STAT3, STAT4 genes increase UC susceptibility [19], and JAK3 knockout mice develop severe combined immunodeficiency, affecting T and B cell development, resulting in IEC differentiation defects and impaired intestinal barrier function, thus increasing susceptibility to UC [131]

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