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For example, CAN often presents with resting tachycardia and orthostatic hypotension, so nonpharmacologic strategies (such as adequate salt intake and physical activities and avoidance of medicine-related hypotension) and pharmacologic strategies (such as midodrine and droxidopa) should be considered to minimize postural symptoms rather than to restore normotension

The deficiency may be the result of reduced dietary intake, but a more likely explanation is as we age there is reduced secretion of a compound known as intrinsic factor that facilitates B12 absorption