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doi: 10.3389/fnbeh.2026.1805953 Received 06 February 2026 Revised 13 March 2026 Accepted 13 March 2026 Published 13 April 2026 Volume 20 - 2026 Edited by Emmanuel Darcq, Institut National de la Sant et de la Recherche Mdicale (INSERM), France Reviewed by Zhe Zhao, Max Planck Florida Institute for Neuroscience (MPFI), United States Madhawi Aldhwayan, King Saud University, Saudi Arabia Updates Copyright 2026 OConnor

A complete 48-week protocol at standard titration pace requires roughly three to four 20mg vials at minimum, depending on how long you hold at each tier

Plasma drug concentrations during a 12-hour dosing interval varies, by almost 120% for the oxtriphylline product but only 48% for the anhydrous tablet (Theo-Dur), suggesting it may be the best product for use in dogs

It contributes to several key aspects of the products it infuses reduce it, and everything moves