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Its efficacy in lowering hemoglobin A1c levelsa marker of average blood glucose over the past two to three monthshas been well documented in clinical trials, showcasing its superiority over other antidiabetic agents in certain cases

While caffeine itself does not worsen the side effects of semaglutide, excessive caffeine intake can cause symptoms such as nausea, anxiety, and insomnia, which may overlap with some of semaglutides side effects

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Large cardiovascular outcome trials have demonstrated that several agents in this class reduce major adverse cardiovascular events (MACE) in patients with type 2 diabetes, with benefits extending beyond just those with established cardiovascular disease in some trials