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In contrast, a worsened clinical course, higher hypermagnesemia, and emerging hyperkalaemia might cause both l-NAME and l-arginine to affect the same events adversely

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MIA reprograms microglia in a phenomenon known as trained immunity (otherwise known as innate immune memory) to enhance immune responses or suppress immune pathways to confer immune tolerance [51] via epigenetic modulations involving histone modifications, DNA methylation, chromatin remodeling, and miRNAs [52]