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The SURMOUNT-4 trial demonstrated 25.3% total body weight loss over 88 weeks in the treatment continuation group

Conclusions This study demonstrated no benefit from six months treatment with VPA and L-carnitine in a young non-ambulatory cohort of subjects with SMA

generally mild to moderate and transient Vomiting Diarrhoea or constipation Abdominal pain or bloating Reduced appetite an intended therapeutic effect, but may affect nutritional intake Fatigue, particularly during the initial weeks of treatment Injection site reactions: redness, bruising, or mild discomfort Less common but clinically significant side effects Seek prompt medical attention if you experience any of the following: Pancreatitis: severe, persistent upper abdominal pain, often radiating to the back