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PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)

Review of the pharmacokinetics of French maritime pine bark extract (Pycnogenol) in humans

Sucrose preference test For clarity and adherence to the experimental timeline, the sucrose preference test was performed after these behavioral tests to assess the impact of PCPA-induced insomnia on sucrose preference in the animals