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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Jedlitschky G., Leier I., Buchholz U., Center M., Keppler D

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The presence of chronic hyperglycemia, insulin resistance, oxidative stress, and pro-inflammatory mechanisms contribute to endothelial dysfunction in patients with diabetes mellitus (61)

Lifehacks: If you think you may need to boost your glutathione levels due to oxidative stress and genetic polymorphisms, there are multiple way you could approach this: Reduce the need for glutathione (reduce toxins) Add more cysteine-rich foods its the limiting factor for glutathione synthesis Also, add glycine if it is limited in your diet Directly supplement with liposomal or IV glutathione Indirectly supplement with cofactors, amino acids (caution here) Avoiding toxicants: Avoiding exposure to the toxicants that deplete glutathione will increase your overall glutathione levels and give you more resistance to oxidative stress