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Efficacy endpoints were change from baseline in HbA 1c and body weight (and, for the separate PIONEER 8 subgroup analysis, change from baseline in insulin dose) at the planned end of treatment (weeks 26, 52 or 78, according to the trial)

The OASIS 4 clinical trial published in the New England Journal of Medicine in 2025 followed adults with overweight or obesity for 71 weeks

Figure 3 shows at a high level how each country can be mapped against indicators of their ability for public reimbursement (GDP per capita) and private spend (out-of-pocket [OOP] expenditure per capita) with the size of the bubble proportional to total 2025 list-price semaglutide sales

The primary objective would not be significant weight loss, but rather the optimization of your metabolic health