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These changes coincided with decreased antioxidant pathways (system xc-, glutathione peroxidase 4, and glutathione) and increased lipid peroxidation

The working hypothesis in the scientific community is that GHK, by delivering copper and interacting with cellular signaling nodes, helps restore a more "youthful" transcriptional signature

Because oral glutathione supplements have historically demonstrated poor bioavailability and are rapidly broken down by enzymes in the gastrointestinal tract, the body relies heavily on intracellular de novo synthesis to maintain its protective antioxidant pools

Clinical Cancer Research 15(24), 2009