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T1r3 and -gustducin in gut regulate secretion of glucagon-like peptide-1

The pathophysiology is unclear, but risk factors are thought to be the same as the type 1 diabetic patients who rapidly improved A1c in the Diabetes Control and Complications Trial: long duration of diabetes mellitus, long duration of poor glycemic control, worse baseline level of DR prior to treatment and magnitude of reduction in A1c after treatment

An alternative conservative start uses 1mg for the first four weeks before moving to 2mg

If you frequently miss doses due to timing challenges, contact your healthcare provider to develop a more sustainable schedule