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This result is suggestive of the constitutive activation of LKB1/AMPK pathway in the livers of KO mice

2019 Endocrinology GH/IGF-1 Axis Research model for studying GHRH receptor pharmacology, GH secretagogue effects, and downstream IGF-1 modulation in the context of GH deficiency states and aging-related GH decline

doi:10.1038/s41467-025-60844-9

A landmark review published in Biomolecules documenting GHK-Cus regulatory effects on over 4,000 human genes, including significant upregulation of collagen synthesis, anti-inflammatory pathways, and stem cell mobilization established the molecular basis for its clinical use