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An important property of caffeine is that it can easily pass through the blood-brain barrier [54]

In guinea pigs, the administration of curcumin and encapsulated DEX prior to treatment effectively mitigated the ototoxic effects of cisplatin, thereby safeguarding auditory function across all frequencies

Pterostilbene treatment of 15 and 30 M showed reduced histamine secretion and calcium uptake, overall indicating its ability to prevent degranulation, histamine release, and intracellular calcium level of mast cells [209]

There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)