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However, it is thought that ME/CFS may have a genetic predisposition (26, 29, 56, 61, 6568) as members of the same family have frequently been diagnosed with ME/CFS (65, 67, 68), though they will also tend to share similar lifestyles and cultures

[PubMed: 3126809] 767

Therefore, we identified GSTM2 as an important negative regulator in progression of hepatic steatosis via both its detoxification/antioxidant and inhibition of ASK1-p38/JNK signalling

it also appears that it may affect lipolysis by binding to the MC5R