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GLP-1 receptor agonists may potentially reduce inflammation and oxidative stress in adipose tissue by affecting the expression of cytokines, chemokines, and macrophage infiltration, with prolonged GLP-1 action potentially alleviating obesity-related adipose tissue inflammation while enhancing the expression of anti-inflammatory genes [17,18] (Figure 2)

Our earlier preview of the seven peptides under FDA review explains what each compound does and why it was nominated.

Shaking the vial vigorously can create shear forces that physically break these chains apart, damaging the peptides structure and rendering it ineffective

10.1016/j.cell.2011.10.018 Cell 177 WangZ