Lee SW, Yon DK, James CC, Lee S, Koh HY, Sheen YH, Oh JW, Han MY, Sugihara G
It is an amino acid derivative that is stored throughout the body, especially in the brain, heart and muscles, and whose main function is to transport fatty acids to the mitochondria in the cells for energy production
A 2014 mouse study found that NAC and vitamin E accelerated lung tumor progression and reduced survival.41 A 2015 melanoma mouse study found that NAC increased lymph node metastases in mice with malignant melanoma.42 A 2019 mouse study reported that NAC protected against emphysema-related lung damage but also induced lung adenocarcinoma in some mice.43 And a 2021 hepatocellular carcinoma study found that antioxidant supplements including NAC promoted tumor formation, growth, and drug resistance in experimental models by reducing intracellular ROS.3 Newer human data add another layer of complexity
(2014) Pretherapeutic gamma-glutamyltransferase is an independent prognostic factor for patients with renal cell carcinoma, Br