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MNs/GLP-1RAs@NPs-WYRGRL suppressed the progression of RA through promoting the polarization of synovial macrophages to the M2 type To clarify whether MNs/GLP-1RAs@NPs-WYRGRL could alleviate the inflammatory response of RA by regulating the polarization state of synovial macrophages, this study detected the types of synovial macrophages and the cytokines they secrete in each group

(1-36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic -cell function, growth and survival

So, if you cannot tolerate the standard max, your effective dose might be a bit lower

10.1186/s12902-017-0213-3 BMC Endocr