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They have the GLP-1 receptor, they're activated, but there also is an inhibitory tone on the AgRP and NPY neurons, and it fits very well with that

That means the vast majority of people who could get their medication covered simply give up at the first no

This principle matters more on a GLP-1 drug because the margin for error shrinks

was supported by MRC (MR/S025618/1) and Diabetes UK (17/0005681) Project Grants, as well as a UKRI ERC Frontier Research Guarantee Grant (EP/X026833/1)