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Given the intimate association between skeletal muscle function, glucose and fat metabolism in health and disease, these agents already marketed for DM deserve more thorough scrutiny as a potential therapeutic avenue for sarcopenia
293 , L753L761 (2007)
Glutathione Peroxidases Glutathione peroxidases (Gpx) are selenium-containing enzymes that degrade hydrogen peroxide and hydroperoxides to water and to alcohols, respectively, by using an active site seleno-cysteine that is transformed into the selenenic (Se-OH) oxidized form and is reduced back to the selenolate (Se-H) form by glutathione
Interestingly, in a mouse model of NASH, 2 weeks of treatment with a oxyntomodulin analog also ameliorated the hepatic histopathological features of this disease (77)
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