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Collectively these data cast doubt as to the contribution of inhibition of complex 1 as the primary target and explanation for the therapeutic effects of metformin both as an anti-diabetic and as an anti-aging drug

It becomes part of their morning ritual, like taking vitamins

GLP-1 receptor agonists, such as semaglutide (sold under the brand name Ozempic or Wegovy) and tirzepatide (brand name Mounjaro or Zepbound), are medications originally developed for diabetes and now approved for chronic weight management at specific doses

Weight outcomes track that discontinuation curve exactly: patients who never discontinue lose roughly 11.9% body weight at one year in the real world