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Since peptides, proteins, and hormones can directly reach the brain when administered intranasally via transport and diffusion along the olfactory and trigeminal nerves [241], future studies should explore whether intranasal melatonin could be a viable therapeutic option for increasing brain melatonin levels in individuals at risk of developing AD
Administration Depending on current best practices, treatment may be via injection or other medically approved delivery
Cheng WH, Ho YS, Ross DA, Valentine BA, Combs GF Jr, Lei XG
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