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A 2004 review in Endocrine Reviews noted that growth hormone secretion is tightly linked to sleep architecture

Adv Ther 39(6):24522467 Davies MJ et al (2015) Efficacy of liraglutide for weight loss among patients with type 2 diabetes: the SCALE diabetes randomized clinical trial

In its original 1998 characterization, ipamorelin released growth hormone without significantly raising cortisol, ACTH, or prolactin, which set it apart from earlier growth hormone-releasing peptides such as GHRP-6 and GHRP-2