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However, studies on mice showed that GPx4 suppresses increasing levels of vascular endothelial growth factor A (VEGF-A), which increase during neovascularization [82]

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The need for enduring and effective interventions is further underscored by the prevalence of GI side effects and rare but serious complications, such as pancreatitis and bowel obstruction, alongside the critical importance of preserving lean body mass [13,14]