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[19] Patients should maintain adequate hydration during the initial treatment period, as gastrointestinal side effects can increase dehydration risk, which may lead to acute kidney injury in severe cases

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Testicular blood flow was evaluated through scanning of the supra-testicular artery (STA) spectral patterns through pulsed Doppler ultrasonography [peak systolic velocity (PSV), end-diastolic velocity (EDV), time average maximum velocity (TAMAX), resistive index (RI), and pulsatility index (PI)], while the echotexture assessment of testicular parenchyma was performed by a computerized software program