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Additional information Peer review information Nature Reviews Cardiology thanks the anonymous reviewer(s) for their contribution to the peer review of this work

doi: 10.2147/DDDT.S82030

These exacerbations of dementia symptoms were ameliorated by sustained descent to a lower elevation than his home, as reported in the literature ( This case suggests the bioactivity of the unappreciated component of hyperbaric therapy, barometric pressure, due to the known similar effects in treatment of mountain sickness ( The precedence for our patient's improvement dates back to the 300-year initial history of hyperbaric therapy, which consisted solely of compressed air usage ( The contribution of glutathione (GSH) amino acid precursors to our patient's recovery is impossible to prove but is suggested by the neuroprotective properties of GSH ( Intracellular GSH levels are controlled by Nrf2 expression ( This case report did not include functional imaging documentation